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|Pronunciation||/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil|
|Trade names||Viagra, Revatio, others|
|License data||EU EMA: by INN, US FDA: Sildenafil|
|Pregnancy category||AU: B1 US: B (No risk in non-human studies)|
|Routes of administration||By mouth (tablets), IV|
|ATC code||G04BE03 ( WHO )|
|Legal status||AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)|
|Bioavailability||41% (mean) |
|Metabolism||Liver: CYP3A4 (major route), CYP2C9 (minor route)|
|Metabolites||N -desmethylsildenafil (~50% potency for PDE 5 )|
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Sildenafil is classified as FDA pregnancy risk category B. Fluvoxamine is likely to have sildenafil sublingual interaction with similar agents such as tadalafil and vardenafil since they are also metabolized by CYP3A4.
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It was also reported that the effects of sildenafil were independent of cardiac afterload or preload changes. Dosage adjustments may be needed based on clinical efficacy. Forty consecutive patients with erectile dysfunction for more than three months were included in the study.
Post-marketing serious cardiovascular, cerebrovascular, and vascular adverse events were reported in temporal association with sildenafil use and include myocardial infarction, propecia pills cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, subarachnoid and intracerebral hemorrhages or intracranial bleeding, and pulmonary hemorrhage and clonidine frequent urination.
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|These effects are possibly related to the effects of sildenafil on PDE5 in vascular smooth muscle||Erectile dysfunction is a state when the man who desires sexual intercourse is unable to get the fullest erection of organ to have a highly satisfying sexual intercourse||Dosing scheme and assessments for the evaluation of pharmacokinetic parameters in 20 patients with psychogenic erectile dysfunction EDsubdivided into three groups respectively||Sildenafil is generally taken 30 to 60 minutes prior to sexual intercourse|
|Sublingual use of sildenafil may be more cost-effective and possibly provides a more predictable onset of action||Find user ratings and reviews for sildenafil citrate on WebMD including side effects and drug interactions||However||Sildenafil has also shown efficacy in treating altitude sickness|
|Additionally||There are no adequate and well-controlled studies of sildenafil in pregnant women||Complete disintegration is defined as that state in which any residue of the unit remaining on the screen of the test apparatus or adhering to the lower surface of the discs is a soft mass having no palpably firm core||Sildenafil was originally developed as an antianginal agent but was found to be more effective in treating erectile dysfunction ED|
|Grapefruit juice food has been reported to decrease the metabolism of drugs metabolized by the CYP 3A4 isozyme||Alcohol intake should restricted to achieve maximum effect||The only difference between the two is the price||Based on these pharmacokinetic data|
|Sildenafil is the first oral therapy approved for treating early stages of PAH||Flavia Rosano and Dr||The areas of the brain that have the highest activity of PDE5 are the hippocampus||Altered sildenafil serum concentrations may occur|
|Sildenafil is contraindicated for use with the anti-retroviral protease inhibitors when used for pulmonary arterial hypertension PAH||There is no safety information on the administration of sildenafil to patients with known hereditary degenerative retinal disorders||Results were compared with the original formulation of Sild||During the second 3 months the patients were asked to take Sildenafil for sublingual administration crushing the pill in the mouth and dissolving the drug under the tongue 15 minutes before planned sexual relations|
Indeed, this phenomenon is generally pursued for oral trans-mucosal drugs, where the use of mucoadhesive polymers is recommended to assure prolonged period of contact between the formulation and the oral mucosa Lam et al. Sildenafil is regarded as the most popular erectile dysfunction drug.
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Sildenafil has no direct relaxant effect on isolated human corpus cavernosum and, at recommended doses, has no effect in the absence of sexual stimulation. It is not known if sildenafil or its metabolites are excreted in human breast milk.
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Sildenafil citrate Professional works just like brand medication to inhibit the enzyme known as PDE5. Based on these pharmacokinetic data, it is recommended not to exceed a maximum single dose of 25 mg sildenafil in a 48 hour period. Price for propecia pills viagra buy cheapest 25mg online without prescription super pfizer tablets sildenafil mg get cost low.
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|The American College of Cardiology recommends that sildenafil be used with caution in the following||If possible||Sildenafil is administered sublingually||Sildenafil is rapidly absorbed after sublingual administration|
|Sildenafil is regarded as the most popular erectile dysfunction drug||Do not use alcohol while using this medicine||This list may not describe all possible interactions||Only use a PDE5 inhibitor in these individuals if the anticipated benefit outweighs the risk|
|Compared with conventional processing this technique is dramatically simpler||Sildenafil continues to be studied clinically to assess its utility in treating sexual dysfunction in females||Sildenafil is contraindicated for use with the anti-retroviral protease inhibitors when used for pulmonary arterial hypertension PAH||Sildenafil has also shown efficacy in treating altitude sickness|
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Particular caution should be used when prescribing phosphodiesterase type 5 PDE5 inhibitors to patients receiving sublingual sildenafil citrate. Based on these pharmacokinetic data, it is recommended not to exceed a maximum single dose of 25 mg sildenafil in a 48 hour period. All the patients were reported to appreciate this method of administration, particularly in the case of unplanned sexual relations.
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Both sildenafil and its active metabolite have terminal half-lives zithromax price about 4 hours. Serum glucose and testosterone levels, lipid profile and erectile function scores were obtained in all patients.
FCT, considered as reference formulation, was classically administered per os by swallowing the oral tablet with a glass of water.
Both sildenafil and its active metabolite have terminal half-lives of about 4 hours. Its pharmacokinetics are dose-proportional over the recommended dose range.
Discussion In this study, we provide evidence that the sublingual route of Sild administration associates with an increased early drug bioavailability and improved tolerability profile. Altered indinavir plasma concentrations may result.
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Sildenafil is a vasoactive agent that is commonly prescribed to treat erectile dysfunction impotence in men, and to reduce symptoms in patients with pulmonary arterial sublingual sildenafil citrate PAH. Sildenafil use has also been listed as a potential factor in a http://casastristes.org/apcalis/how-to-take-zithromax number of related web page physical assault, and rape cases.
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In course of erectile dysfunction ED, the impaired production of NO from the endothelial cavernous vessels can be pharmacologically overcome by the use of PDE5 inhibitors PDE5i, in order to prolong the cGMP half-life and to enhance the residual vasodilating function Hawksworth and Burnett, The reason for the increased risk of pain is unknown; however, in the initial trial, patients were aggressively treated with transfusions and hydroxyurea to control crises; the larger trial offered no intervention for crises.
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